GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6479874 | 1 | rs7076631 | chr10:52759323 | PRKG1 | chr10:52750945-54055274:+ | -0.2 | -4.65 | 4.3E-6 | Migraine |
| THCA | cis | rs12220238 | 1 | rs7076721 | chr10:75996682 | VCL | chr10:75754951-75879912:+ | -0.18 | -3.38 | 0.000795 | Soluble interleukin-2 receptor subunit alpha |
| THCA | cis | rs7078003 | 1 | rs7078003 | chr10:99359412 | DHDPSL | chr10:99344102-99372553:+ | 0.31 | 4.4 | 1.34E-5 | Metabolite levels (small molecules and protein measures) |
| THCA | cis | rs7078219 | 1 | rs7078219 | chr10:101274365 | NKX2-3 | chr10:101292690-101296278:+ | 0.32 | 5.67 | 2.43E-8 | Dental caries |
| THCA | cis | rs11190604 | 1 | rs7078799 | chr10:102301447 | SEC31B | chr10:102246403-102289636:- | -0.28 | -9.04 | 3.94E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs7079041 | 1 | rs7079041 | chr10:32993268 | C10orf68 | chr10:32856598-33171791:+ | 0.21 | 4.86 | 1.58E-6 | Suicide in bipolar disorder |
| THCA | cis | rs11190604 | 1 | rs7079136 | chr10:102292709 | SEC31B | chr10:102246403-102289636:- | -0.28 | -9.14 | 1.74E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs1398024 | 1 | rs7079237 | chr10:23659587 | C10orf67 | chr10:23605521-23633772:- | -0.23 | -4.6 | 5.31E-6 | Crohn's disease and sarcoidosis (combined) |
| THCA | cis | rs7079679 | 1 | rs7079679 | chr10:102055546 | CWF19L1 | chr10:101992055-102027437:- | -0.25 | -4.68 | 3.68E-6 | Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) |
| THCA | cis | rs11190604 | 1 | rs7079756 | chr10:102302105 | SEC31B | chr10:102246403-102289636:- | -0.28 | -9.28 | 6.11E-19 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs6585827 | 1 | rs7079976 | chr10:124172108 | PLEKHA1 | chr10:124134220-124191866:+ | -0.21 | -5.75 | 1.61E-8 | Height |
| THCA | cis | rs11190604 | 1 | rs7080356 | chr10:102266735 | SEC31B | chr10:102246403-102289636:- | -0.27 | -8.69 | 5.7E-17 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs6479874 | 1 | rs7080757 | chr10:52759553 | PRKG1 | chr10:52750945-54055274:+ | -0.2 | -4.66 | 4.1E-6 | Migraine |
| THCA | cis | rs11255291 | 1 | rs7080828 | chr10:7733770 | ITIH5 | chr10:7601636-7708934:- | -0.18 | -3.72 | 0.00022 | Ovarian reserve |
| THCA | cis | rs10904908 | 1 | rs7081155 | chr10:17263140 | TRDMT1 | chr10:17184983-17243681:- | 0.25 | 5.59 | 3.77E-8 | Cholesterol, total |